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Guyer is a surname. Notable people with the surname include:

  • Brandon Guyer (born 1986), American professional baseball outfielder
  • Cindy Guyer, American model and actress
  • Denis Guyer (born 1966), American politician
  • Gino Guyer (born 1983), American professional ice hockey centre
  • Gordon Guyer (born 1926), president of Michigan State University from 1992 to 1993
  • Jane I. Guyer, George Armstrong Kelly Professor in the Department of Anthropology at The Johns Hopkins University
  • Lux Guyer (1894–1955), Swiss architect
  • Paul Guyer, Jonathan Nelson Professor of Philosophy at Brown University
  • Reyn Guyer (born 1935), American inventor
  • Tennyson Guyer (1913–1981), member of the United States House of Representatives
  • Thad McIntosh Guyer (born 1950), American civil rights lawyer
  • U. S. Guyer (1868–1943), U.S. Representative from Kansas