Guînes is a commune in the Pas-de-Calais department in northern France. Historically it was spelt Guisnes.
Guines may refer to:
- Güines, a city in Cuba
- Guînes, a commune in France
Güines is a municipality and town in the Mayabeque Province of Cuba. It is located southeast of Havana, next to the Mayabeque River. It is the most populated town, but not the capital, of its province.