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Guemes or Güemes may refer to:

  • De Güemes, a Spanish surname
  • Guemes Island, a small island in western Skagit County, Washington state, USA
  • General Güemes, Salta, a town in the center of the province of Salta, Argentina
  • General Güemes Department, Chaco, the largest and the northernmost department of Chaco Province in Argentina
  • General Güemes Department, Salta, Salta Province, Argentina
  • Martín Miguel de Güemes, Argentine 19th century military leader