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n. (context biochemistry genetics organic compound English) A nucleoside derived from guanine and ribose.


n. a nucleoside component of DNA; composed of guanine and deoxyribose [syn: deoxyguanosine]


Guanosine is a purine nucleoside comprising guanine attached to a ribose ( ribofuranose) ring via a β-N- glycosidic bond. Guanosine can be phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP). These forms play important roles in various biochemical processes such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction, and intracellular signal transduction (cGMP). When guanine is attached by its N9 nitrogen to the C1 carbon of a deoxyribose ring it is known as deoxyguanosine.

The antiviral drug aciclovir, often used in herpes treatment, and the anti-HIV drug abacavir, are structurally similar to guanosine.

Guanosine is required for an RNA splicing reaction in mRNA, when a "self-splicing" intron removes itself from the mRNA message by cutting at both ends, re-ligating, and leaving just the exons on either side to be translated into protein. Guanosine was used to make Regadenoson.

Usage examples of "guanosine".

But his pronunciation of, say, guanosine triphosphate, seemed to give this benign molecule explosive properties.

Enzymes are like assembly-line workers, each specializing in a particular molecular job: Step 4 in the construction of the nucleotide guanosine phosphate, say, or Step 11 in the dismantling of a molecule of sugar to extract energy, the currency that pays for getting the other cellular jobs done.