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GSD may refer to:

  • Garsdale railway station, England, National Rail station code GSD
  • People's Liberation Army General Staff Department
  • Gender and Sexual Diversity, alternative terminology mooted for LGBT etc
  • General Station Device, a file with the characteristics of an IO PROFINET Device
  • Genetic significant dose, a measurement of the effect of gonad radiation dose
  • Geometric standard deviation, how spread out are a set of numbers whose preferred average is the geometric mean
  • Georgia School for the Deaf
  • German Shepherd dog, a breed of medium to large-sized dog that originated in Germany
  • Gestational sac diameter
  • Gibraltar Social Democrats, a centre-right political party in Gibraltar
  • Global Species Database
  • Glutathione synthetase deficiency
  • Glycogen storage disease
  • Glycogen storage disease type II, or Pompe disease
  • Go Skateboarding Day
  • Harvard Graduate School of Design
  • Graphical system design
  • Graphtec Vector Graphic Data, a file extension
  • Great Sandy Desert
  • Great Sun of Discovery, the first year (AD 1492) of a dating system used by the Improved Order of Red Men
  • Ground sample distance
  • Mobile Suit Gundam SEED Destiny, a 2004 anime television series, acting as a sequel of Mobile Suit Gundam SEED by Sunrise