Grand-Popo is a town, arrondissement, and commune in the Mono Department of south-western Benin. The commune covers an area of 289 square kilometres and as at the 2013 Census had a population of 57,490 people.
The Finno-African culture center Villa Karo has been situated in Grand-Popo since 1999.
The town grew around the slave trade, but coastal erosion has now destroyed most of the old town. The town is now a center for voodoo and home to a Finnish- African cultural centre, Villa Karo. The town's main industry is fishing.
The town inspired the name of the French electronic music duo Grand Popo Football Club, as well as the name of the iPad application creator Grand Popo LLC.