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glypiation

n. (context biochemistry English) The attachment of glycosylphosphatidylinositol to a protein as a posttranslational modification

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Glypiation

Glypiation is the covalent bond of a glycosylphosphatidylinositol (GPI) anchor and is a common post-translational modification that localizes proteins to cell membranes. This special kind of glycosylation is widely detected on surface glycoproteins in eukaryotes and some Archaea.

GPI anchors consist of a phosphoethanolamine linker that binds to the C-terminus of target proteins. Glycan's core structure has a phospholipid tail that anchors the structure to the membrane.

Both the lipid moiety of the tail and the sugar residues in the glycan core has considerable variation, demonstrating vast functional diversity that includes signal transduction, cell adhesion and immune recognition. GPI anchors can also be cleaved by enzymes such as phospholipase C to regulate the localization of proteins that are anchored at the plasma membrane.