What is "glycorandomization"

alt. (context organic chemistry English) The manufacture of a large series of related compounds, containing various sugar moieties, for investigation as pharmaceuticals etc. n. (context organic chemistry English) The manufacture of a large series of related compounds, containing various sugar moieties, for investigation as pharmaceuticals etc.

Glycorandomization, is a drug discovery and drug development technology platform to enable the rapid diversification of bioactive small molecules, drug leads and/or approved drugs through the attachment of sugars. Initially developed as a facile method to manipulate carbohydrate substitutions of naturally-occurring glycosides to afford the corresponding differentially glycosylated natural product libraries, glycorandomization applications have expanded to include both small molecules (drug leads and approved drugs) and even macromolecules ( proteins). Also referred to as 'glycodiversification', glycorandomization has led to the discovery of new glycoside analogs which display improvements in potency, selectivity and/or ADMET as compared to the parent molecule.