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GLS can mean:

  • Gallium lanthanum sulfide glass
  • Games, Learning, & Society Conference
  • Gate-level simulation, used for a hardware design.
  • General Lighting Service, a designation of an incandescent lamp standard
  • General Logistics Systems, a logistics company
  • Generalized least squares in the linear regression model
  • The George Lopez Show
  • Glaisdale railway station, England (National Rail station code GLS)
  • Glasgow Literary Society, founded in 1753, a key institution of the Scottish Enlightenment
  • Global Locating System, a generalized technique to geolocate remote assets. Used commercially by Skybitz
  • Gloucestershire (GLS is the Chapman code for this English county)
  • GBAS Landing System, in aviation, a precision approach system to an airport
  • Government Legal Service, Legal Services for the UK Government and services
  • Graeco-Latin square, a pair of orthogonal Latin squares
  • Great Lake Swimmers, a Canadian indie folk band
  • Guided Local Search, a search algorithm in computer science
  • Guy L. Steele Jr., an American computer scientist
  • Scholes International Airport at Galveston, IATA airport code
  • Global Leadership Scholars, an undergraduate business honors program at University of Tennessee