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The GLIC receptor is a bacterial (Gloeobacter) Ligand-gated Ion Channel, homolog to the nicotinic acetylcholine receptors. It is a proton-gated, cation-selective channel, and like the nicotinic acetylcholine receptors is a functional pentameric oligomer. However while its eukaryotic homologues are hetero-oligomeric, all until now known bactria known to express LICs encode a single monomeric unit, indicating the GLIC to be functionally homo-oligomeric.

The similarity of amino-acid sequence to the eukaryotic LGICs is not localized to any single or particular tertiary domain, indicating the similar function of the GLIC to its eukaryotic equivalents. Regardless, the purpose of regulating the threshold for action potential excitation in the nerve signal transmission of multicellular organisms cannot translate to single-cell organisms, thereby not making the purpose of bacterial LGICs immediately obvious.