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GLB may refer to:

  • GLB (gay, lesbian and bisexual), formerly known as the "gay community" (see LGBT)
  • Girls' Life Brigade, a constituent organization of the Girls' Brigade international and interdenominational Christian youth organization
  • glomus-like bodies
  • Goal Line Blitz, a browser-based, American football massive multiplayer online role playing game
  • Gramm–Leach–Bliley Act, an act of the 106th United States Congress that repealed part of the Glass–Steagall Act of 1933
  • Grant Lee Buffalo, a rock band based in Los Angeles, California
  • Greatest lower bound (see Infimum and supremum)