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Wiktionary
give up the ghost

vb. 1 (context intransitive idiomatic English) To cease clinging to life; to die. 2 (context intransitive idiomatic figuratively English) To quit; to cease functioning. 3 (context intransitive with ''of'' English) To cede a commitment to or identification with.

Wikipedia
Give Up the Ghost

Give Up the Ghost is a hardcore punk band from Boston, Massachusetts. They have released two albums, one EP and a compilation of earlier released material under the name American Nightmare.

Give Up the Ghost (album)

Give Up the Ghost is the third studio album by American singer-songwriter Brandi Carlile, released on October 6, 2009, through Columbia Records. The album was produced by Grammy Award winner Rick Rubin and contains a collaboration with Elton John titled "Caroline". Recorded at Sunset Sound in Los Angeles, the album also features Chad Smith, Amy Ray and Benmont Tench.

"Dreams", the first single from the album, was released on Carlile's website on August 14, and was available for download on August 18.

Usage examples of "give up the ghost".

By the end of August, even those would give up the ghost and the city would turn green: glossy beryl banana trees with canoe-sized leaves, jade swamp oak, and acre upon emerald acre of bermuda grass.

The tiny pepper tree he'd planted seemed about to give up the ghost.

She was as a hopeless patient, in the reeking antiseptic death cubicle of a modern hospital, freed at last from the hands of youthful and overzealous doctors, to give up the ghost on a white pillow Enough.

She was as a hopeless patient, in the reeking antiseptic death cubicle of a modern hospital, freed at last from the hands of youthful and overzealous doctors, to give up the ghost on a white pillow alone.

But Salabaetto, being minded to requite her guile with his own, went to her one evening, being bidden to sup and sleep with her, with an aspect so melancholy and dolorous, that he shewed as he had lief give up the ghost.

In general size and shape it bore a faint resemblance to an upended coffin, and had the same brooding, ominous air of a casket waiting for its owner to give up the ghost.

From time to time a sudden sputtering noise would make Steel jump, as one or another piece of machinery would give up the ghost and cease to function.

With all of Southern California to choose from, naturally the thing would decide to give up the ghost in the dead, endless stretch of desert and hill country that lay between Barstow and San Bernardino, miles from anywhere in the middle of Sunday night.

The last thing she needed right now was the light to give up the ghost.

And then, just as the engine whined as if it was about to explode and the whole plane seemed about to give up the ghost, magically it lifted off and soared upward.