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Gius is a surname that appears to be associated with Italy, specifically the Trentino-Alto Adige/Südtirol region that was annexed by Italy from Austria-Hungary in 1919. Anecdotal evidence suggests that the native pronunciation of the surname was similar to "juice" and that at least one Americanization of the surname was pronounced "guy—us".

The Gius surname is shared by several notable people:

  • Julius Gius (1911–1996), American newspaper editor
  • Nicole Gius (born 1980), Italian alpine skier
  • David Gius (born 1960), Physician-Scientist National Cancer Institute