GHC may refer to:
- General Holding Corporation, the United Arab Emirates' largest industrial conglomerate
- Ghanaian cedi, the ISO 4217 code for the currency of Ghana
- Gorkha Hill Council in India
- Group Health Cooperative, in Seattle, Washington
- Glasgow Hardcore - a loose collective of hardcore, punk and crossover thrash bands from Glasgow, Scotland who derive their name from the band Divide's demo "Glasgow Hardcore"
- Global Honored Crown, the names of championships in the Japanese promotion Pro Wrestling Noah
- Grace Hopper Celebration of Women in Computing