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GHB may refer to:

  • gamma-Hydroxybutyric acid, a drug used to treat narcolepsy (a controlled substance in some countries)
  • glycated hemoglobin, a form of hemoglobin created during its exposure to high plasma levels of glucose
  • Gabo d'Hirutho d'Bethnahrin, a militant Assyrian party labeled by the Turkish Government as a terrorist group
  • Great Highland Bagpipe, a variety of bagpipe
  • Gerakan Harapan Baru, a political movement in Malaysia
  • George H. Bush, 41st President of the United States of America
  • Governor's Harbour Airport, an airport in the Bahamas