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GFC may refer to:

  • Global Fighting Championship
  • Games For Canada
  • Generic flow control, in the Asynchronous Transfer Mode of telecommunications
  • GEROVA Financial Group, NYSE code
  • "GfC", 2008 single from the album ¿Cómo Te Llama?
  • Global F.C., an association football club in the Philippines
  • Global Forest Coalition
  • Global Financial Crisis (see Financial crisis of 2007–08), which led to the Great Recession