What is "fusafungine"

alt. An active agent used in antibiotics for treatment of nasal and throat infections. n. An active agent used in antibiotics for treatment of nasal and throat infections.

Fusafungine ( INN), also known as fusafungin, is an active agent used in antibiotics for treatment of nasal and throat infection. It also possesses anti-inflammatory properties. Fusafungine is a mixture of enniatin cyclohexadepsipeptides made up of alternating D-α-hydroxyvaleric acid and L-N-methylamino acid residues, produced by the ascomycete Fusarium lateritium, and marketed by Servier under the trade names Locabiotal, Bioparox, and Locabiosol.

According to a pooled analysis study done in the UK for the efficacy of fusafungine in rhinopharingitis, it was found that the proportion of patients who showed an improvement in symptoms from Day 0 to Day 4 of infection was 61.5% with fusafungine vs. 46.8% when compared to a placebo.

In February 2016, the European Medicines Agency recommended to withdraw fusafungine from the market due to rare but severe allergic reactions (mainly bronchospasms).