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ESX may refer to:

  • VMware ESX, a computer virtualization product
  • ESX, security event, the Electronic Security Expo
  • Dodge Intrepid ESX, a hybrid electric automobile
  • Essex Junction (Amtrak station) (station code ESX), Vermont, United States
  • ESX-1, an Electribe electronic musical instrument
  • Ethosuximide, an anti epileptic drugs paper