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ERCC may refer to:

  • East Riding County Council, Yorkshire, England
  • Excision repair cross-complementing, a set of proteins in humans
  • European Rugby Champions Cup, Europe's top rugby union club competition
    • European Rugby Challenge Cup, the second tier competition
  • Evangelical Reformed Church of Christ, Nigeria
  • External RNA Controls Consortium, a group of industry, academia and government partners that developed a RNA spike-in mix used as a control for RNA sequencing and RNA expression analysis