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EPW may refer to:

  • Earth Penetrating Weapon, a tactical nuclear weapon
  • Economic and Political Weekly, an Indian journal / magazine
  • Electric-powered wheelchair, a form of wheelchair
  • Enemy Prisoner of War, the U.S. military term for enemy prisoners of war (POWs)
  • Exciting Pro Wrestling, a Japanese game series by Yuke's
  • Explosive Pro Wrestling, a professional wrestling promotion