What is "ephenidine"

Ephenidine (also known as NEDPA and EPE) is a dissociative anesthetic that has been sold online as a designer drug. It is illegal in some countries as a structural isomer of the banned opioid drug lefetamine, but has been sold in countries where it is not yet banned.

Ephenidine and related diarylethylamines have been studied in vitro as treatments for neurotoxic injuries, and are antagonists of the NMDA receptor. Ephenidine also possesses substantially weaker affinity for dopamine and norepinephrine transporters (379 nM and 841 nM, respectively) as well as σR (629 nM) and σR (722 nM) binding sites.