What is "endothelin"

n. (context biochemistry English) A vasoconstricting oligopeptide that plays a key role in vascular homeostasis.

Endothelins are peptides that constrict blood vessels and raise blood pressure. They are normally kept in balance by other mechanisms, but when they are over-expressed, they contribute to high blood pressure ( hypertension) and heart disease.

Endothelins are 21- amino acid vasoconstricting peptides produced primarily in the endothelium having a key role in vascular homeostasis. Endothelins are implicated in vascular diseases of several organ systems, including the heart, general circulation and brain.