Wikipedia
The end-around is a play in American football in which a wide receiver crosses the backfield towards the opposite end of the line and receives a handoff directly from the quarterback. The receiver then may proceed to do one of two things: he either runs the ball towards the line of scrimmage in order to gain yardage, or more rarely, attempts to pass to another eligible pass receiver. Both versions of the end-around are uncommon and can be considered trick plays.
The end-around should not be confused with an end reverse, in which the receiver takes a handoff from a player who has already taken a handoff from the quarterback.
End-arounds are usually preferred to reverses in the NFL; although they are less convincing, they offer lower risk. End-arounds offer less chance of a fumble, as there is only one handoff rather than two. Also, end-arounds require less time to complete, thus reducing the chance of a large loss of yardage.