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Efren or Efrén may refer to:

  • Efrén Echeverría (born 1932), musician guitarist, composer, and compiler from Paraguay
  • Efrén Pérez Rivera (born 1929), former college professor and noted Puerto Rican environmentalist leader
  • Efrén Vázquez (born 1986), Spanish Grand Prix motorcycle road racer in the 250 cc World Championship riding a Derbi
  • Efren de la Cruz (born 1989), Ecuadorian footballer who plays for LDU Quito
  • Efren Herrera (born 1951), former American football place-kicker and wide receiver in the National Football League
  • Efren Peñaflorida (born 1981), teacher and social worker in the Philippines
  • Efren Ramirez (born 1973), American actor
  • Efren Reyes (born 1954), Filipino professional pool player from Angeles City and a two-time world champion
  • Efren Saldivar (born 1969), American serial killer who murdered patients while working as a respiratory therapist
  • Efren Torres (born 1943), former a Mexican boxer, who was world champion in the Flyweight division