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DXS may refer to:

  • Department of External Services, a fictional U.S. intelligence agency on the TV show MacGyver
  • Dexus Property Group, Australian stock exchange ticker symbol
  • DXS, a web service component formerly known as Get Hot New Stuff in KDE Software Compilation 4
  • Deep Extragalactic Survey, one of five components of the UKIRT Infrared Deep Sky Survey
  • Diffuse X-ray Spectrometer, instrumentation on the NASA Space Shuttle mission STS-54