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DXD can refer to:

  • Destruction By Definition, ska-core band The Suicide Machines' first album.
  • Digital by Digital, a section of the Cinequest Film Festival's competition
  • Digital eXtreme Definition, a professional audio format
  • Disney Xtreme Digital, a community web site by Disney, similar to MySpace
  • Disney XD, the Disney channel that replaced Toon Disney.
  • High School DxD, a Japanese light novel series written by Ichiei Ishibumi.