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DWB may refer to:

  • Deep water blackout, a loss of consciousness caused by cerebral hypoxia on ascending from a deep freedive or breath-hold dive
  • Deutscher Werkbund (German Work Federation), a German association of artists, architects, designers, and industrialists
  • Deutsches Wörterbuch, one of the most important dictionaries of the German language
  • Dirty White Boys, a 1994 vivid and violent novel by American author Stephen Hunter
  • Doctor Who Bulletin (now Dreamwatch), a British magazine covering science fiction and fantasy films, books and television programmes
  • Dominican Winter Baseball League, a professional baseball league in the Dominican Republic
  • Driving While Black, a phrase in the contemporary American vernacular that refers to the criminalization of black drivers
  • Médecins Sans Frontières (Doctors Without Borders), a secular humanitarian-aid non-governmental organization
  • Dwb: Humid continental climate, with dry winters, under Köppen climate classification
  • DWB (magazine), the oldest literary magazine in Flanders
  • Documenter's WorkBench, a collection of document-processing tools based around troff