What is "duloxetine"

n. (context medicine English) An SNRI (Serotonin and Norepinephrine Reuptake Inhibitor) drug used to treat depression, anxiety, and sometimes pain or urinary incontinence.

Duloxetine, sold under the brand name Cymbalta among others, is a serotonin-norepinephrine reuptake inhibitor (SNRI) created by Eli Lilly. It is mostly prescribed for major depressive disorder, generalized anxiety disorder, fibromyalgia and neuropathic pain.

Duloxetine failed to receive US approval for stress urinary incontinence amid concerns over liver toxicity and suicidal events; however, it was approved for this indication in the UK, where it is recommended as an add-on medication in stress urinary incontinence instead of surgery.