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Dufile (also Dufilé, Duffli, Duffle, or Dufli) was originally a fort built by Emin Pasha, the Governor of Equatoria, in 1879; it is located on the Albert Nile just inside Uganda, close to a site chosen in 1874 by then-Colonel Charles George Gordon to assemble steamers that were carried there overland. Emin and A.J. Mounteney Jephson were confined in the fort during a mutiny in 1888. There followed the Battle of Dufile when the former mutineers, after releasing Emin and Jephson, rallied to fight Mahdist forces. Abandoned by Emin's people in January 1889, Dufile, was later reoccupied and reconstructed by Belgian forces from 1902 to 1907.

The fort, where a ditch and bank enclose an area of 12 acres (4.8 hectares), can be reached by road or boat from Laropi. Emin's old harbour is now the departure point for passenger ferries to Nimule in South Sudan.

Dufile was visited by writer Alan Moorehead and surveyed in July 1965 by a team from Imperial College. The fort was excavated between December 2006 and January 2007 by an international team and recommendations on conservation of the site are on file. Today the name Dufile is applied to a nearby Madi village and sub-county in Moyo District to the east of Laropi. The name Dufile itself is a corruption of the Madi village name Odrupele.