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Duffie or Duffié may refer to:

  • Alfred N. Duffié (1833–1880), French-American soldier and diplomat who served in the Crimean War and the American Civil War
  • Darrell Duffie, Canadian economist
  • Grace Duffie Boylan (1861–1935), American writer
  • John Duffie (born 1945), former pitcher in Major League Baseball
  • Kieran Duffie (born 1992), professional Football player
  • Matt Duffie (born 1990), professional rugby league player
  • Paul Duffie (born 1951), former politician, lawyer and judge in the Canadian province of New Brunswick
  • William R. Duffie (died 2000), forestry engineer and political figure in New Brunswick, Canada