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DRB may refer to:

  • Defence Research and Development Canada, the Canadian Defence Research Board
  • Deutsche Reichsbahn, the German Imperial Railways or its wartime locomotive classes such as the DRB Class 50
  • Deutscher Richterbund, the German Association of Judges
  • 5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole, a chemical compound that inhibits gene transcription
  • Digital Radio Broadcast Specialist, a professional title regulated by the Society of Broadcast Engineers
  • Distributed Ruby
  • DRB-HICOM, a Malaysian automotive company
  • DRB Sports Cars, an Australian sports car company
  • The IATA airport code for Derby Airport (Australia) in Western Australia