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Docosatetraenoylethanolamide

Docosatetraenoylethanolamide (DEA) is an endogenous ethanolamide that has been shown to act on the cannabinoid (CB) receptor. DEA is similar in structure to anandamide (AEA, a recognized endogenous ligand for the CB receptor), containing docosatetraenoic acid in place of arachidonic acid. While DEA has been shown to bind to the CB receptor with similar potency and efficacy as AEA, its role as a cannabinergic neurotransmitter is not well understood.