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DLB may refer to:

  • Dementia with Lewy bodies, a type of dementia closely allied to both Alzheimers and Parkinson's Diseases
  • Dictionary of Literary Biography, a specialist encyclopedia dedicated to literature published by Gale
  • Digital Learning Bank, an internet based resource for public schools in South Australia
  • Dolby Laboratories, a company specializing in audio noise reduction and audio encoding/compression
  • Dont Look Back, a 1967 documentary film by D.A. Pennebaker about Bob Dylan
  • Peter de la Billière, British general, commonly known as DLB for his initials
  • Nickname for Irish TV and radio presenter Ryan Tubridy
  • Dustin Lance Black, an American screenwriter
  • The DLB, a tightly focused musical collective originally formed on 4chan's music board
  • Alternative abbreviation for Advanced Persistent Threat in Computer Security