Dirce (; , , modern Greek , meaning "double" or "cleft") was the wife of Lycus in Greek mythology, and aunt to Antiope whom Zeus impregnated. Antiope fled in shame to King Epopeus of Sicyon, but was brought back by Lycus through force, giving birth to the twins Amphion and Zethus on the way. Dirce hated Antiope and treated her cruelly after Lycus gave Antiope to her; until Antiope, in time, escaped.
In Euripides' lost play Antiope, Antiope flees back to the cave where Amphion and Zethus were born, now living there as young men. They disbelieve her claim to be their mother and refuse her pleas for sanctuary, but when Dirce comes to find Antiope and orders her to be killed, the twins are convinced by the shepherd who raised them that Antiope is their mother. They kill Dirce by tying her to the horns of a bull.
Dirce was devoted to the god Dionysus. He caused a spring to flow where she died, either at Mount Cithaeron or at Thebes, and it was a local tradition for the outgoing Theban hipparch to swear in his successor at her tomb.
Dirce is a genus of moth in the family Geometridae.