Crossword clues for digitoxin
The Collaborative International Dictionary
digitoxin \dig`i*tox"in\ (d[i^]j`[i^]*t[o^]k"s[i^]n), n. (Chem.) A steroid glycoside, one of the cardiotonic chemical substances which is extracted from the foxglove. It is a white, crystalline substance ( C41H64O13), and is a 3-substituted triglucoside of a steroid, related structurally to digitalin and digoxin. It is used as a cardiotonic for treatment of certain heart conditions, such as congestive heart failure. Chemically it is
(3[beta],5[beta])-3-[(O-2,6-Dideoxy-[beta]-D-ribo-hexopyranosyl-(1[rarr]4)-O-2,6-dideoxy-[beta]-D-ribo-hexopyranosyl-(1[rarr]4)-2,
6-dideoxy-[beta]-D-ribo-hexopyranosyl)oxy]-14-hydroxy-card-20(22)-enolide.
The related compounds digitalin and digoxin are also
extracted from the foxglove ( Digitalis lanata and
Digitalis purpurea). The class of steroid glycosides having
cardiotonic properties are refered to as the cardiac
glycoside group.
--MI11
Wiktionary
n. (context organic compound English) A toxic cardiac glycoside, obtained from digitalis, related to cardenolide
WordNet
n. digitalis preparation used to treat congestive heart failure or cardiac arrhythmia
Wikipedia
Digitoxin is a cardiac glycoside. It is similar in structure and effects to digoxin (though the effects are longer-lasting). Unlike digoxin (which is eliminated from the body via the kidneys), it is eliminated via the liver, so could be used in patients with poor or erratic kidney function. However, it is now rarely used in current Western medical practice. While several controlled trials have shown digoxin to be effective in a proportion of patients treated for heart failure, the evidence base for digitoxin is not as strong, although it is presumed to be similarly effective.
Usage examples of "digitoxin".
It contains four glycosides, the most powerful of which is digitoxin, a stimulant that increases cardiac activity, causing the heart and arteries to contract and raising the blood pressure.
Next I have a squint at the kidneys: no digitoxin or digoxin, which was what this was looking like to me.
In the case of Digitalis purpurea with normal purple flowers, the content of purified digitoxin, ascertained by Keller's method, averaged 0.
These variations in colour of the flowers of cultivated digitalis plants induced the author to undertake a study of the activity of the several varieties, based on the digitoxin content of the stem leaves collected from flowering plants.