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n. An orally-active synthetic nonsteroidal oestrogen, first synthesized in 1938 and withdrawn in the 1970s on being identified as a teratogen.


n. a potent estrogen used in medicine and in feed for livestock and poultry [syn: diethylstilboestrol, stilbestrol, stilboestrol, DES]


Diethylstilbestrol (DES) ( INN, USAN, BAN), also known formerly and inappropriately as stilboestrol ( BAN), is a synthetic, non-steroidal estrogen of the stilbestrol group that was first synthesized in 1938. It is also classified as an endocrine disruptor. Human exposure to DES occurred through diverse sources, such as dietary ingestion from supplemented cattle feed and medical treatment for certain conditions, including breast and prostate cancers. From about 1940 to 1971, DES was given to pregnant women in the mistaken belief it would reduce the risk of pregnancy complications and losses.

In 1971, DES was shown to cause clear cell carcinoma, a rare vaginal tumor in girls and women who had been exposed to this drug in utero. The United States Food and Drug Administration subsequently withdrew DES from use in pregnant women. Follow-up studies have indicated that DES also has the potential to cause a variety of significant adverse medical complications during the lifetimes of those exposed. The United States National Cancer Institute recommends women born to mothers who took DES undergo special medical exams on a regular basis to screen for complications as a result of the drug. Individuals who were exposed to DES during their mothers' pregnancies are commonly referred to as "DES daughters" and "DES sons".

Usage examples of "diethylstilbestrol".

The hormones he'd taken--- Premarin for a while and then diethylstilbestrol, orally--- couldn't do anything for his voice, but they had thinned the hair a little across his slightly budding breasts.