DHH can refer to:
- David Heinemeier Hansson, a Danish computer programmer.
- Deaf and Hard of Hearing
- DHH (hedgehog), a human gene that encodes the Desert hedgehog protein.
- DHH phosphatase family.
- Louisiana Department of Health and Hospitals.
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Desert hedgehog or Desert hedgehog homolog (Drosophila), also known as DHH or Dhh, is a mammalian gene in the hedgehog signaling pathway. The human homolog (DHH) is on chromosome band 12q13.1. The protein encoded by this gene is involved in cell signaling. The several mammalian variants of the Drosophila hedgehog gene ( which was the first named) have been named after the various species of hedgehog; the desert hedgehog is honored by this one. The gene is not specific to desert hedgehogs.