What is "dexelvucitabine"

n. A failed experimental drug for the treatment of HIV.

Dexelvucitabine is a failed experimental agent for the management of HIV infection. Dexelvucitabine is a cytidine nucleoside analog and nucleoside reverse transcriptase inhibitor. It was found to inhibit HIV-1 replication in vitro and during Phase II clinical trials, it was found to decrease mean viral load in patients with HIV.

On April 3, 2006, Pharmasset and Incyte, the pharmaceutical companies developing dexelvucitabine announced the decision to cease further trials and development of the drug due to an increased incidence of grade 4 hyperlipasemia (an excess of the pancreatic enzyme, lipase) in a phase II trial.

Category:Abandoned drugs Category:Dihydrofurans Category:Nucleoside analog reverse transcriptase inhibitors Category:Organofluorides Category:Pyrimidones