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The Collaborative International Dictionary
Desynonymize

Desynonymize \De`syn*on"y*mize\, v. t. To deprive of synonymous character; to discriminate in use; -- applied to words which have been employed as synonyms.
--Coleridge. Trench.

Wiktionary
desynonymize

vb. To deprive of synonymous character; to cause no longer to be synonyms.