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The Collaborative International Dictionary
Despondence

Despondence \De*spond"ence\, n. Despondency.

The people, when once infected, lose their relish for happiness [and] saunter about with looks of despondence.
--Goldsmith.

Douglas Harper's Etymology Dictionary
despondence

1670s, from Latin despondere "to give up, lose, lose heart, resign, to promise in marriage" (especially in phrase animam despondere, literally "give up one's soul"), from the sense of a promise to give something away, from de- "away" (see de-) + spondere "to promise" (see spondee). A condition more severe than despair.

Wiktionary
despondence

n. The state of being downcast or despondent.

WordNet
despondence

n. feeling downcast and disheartened and hopeless [syn: despondency, heartsickness, disconsolateness]

Usage examples of "despondence".

Few, if any, of her intimates had ever had such sound reasons for despondence as bond-sundered Andorians.