Deluna, DeLuna,or de Luna may refer to:
- Álvaro de Luna (c. 1389-1453), Spanish politician
- Carlos DeLuna (1962-1989), executed (Texas, USA) after controversial conviction
- Jeff de Luna (born 1984), Filipino pool player
- Kat DeLuna, American pop/R&B singer
- Pedro de Luna (1328–1423), Avignon Pope Benedict XIII
- Tristán de Luna y Arellano (1519–1571), Spanish Conquistador
Translated from Spanish to English, "De" means "Of" and "Luna" means "Moon".