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DeLuca, Deluca or De Luca may refer to:

  • Adrian Deluca (born 1982), former Australian rules footballer
  • Anthony DeLuca (disambiguation), various people
  • Frank Deluca (1898-1967), Italian-American mobster and brother of Joseph DeLuca
  • Fred DeLuca (1948-2015), American businessman and co-founder of the Subway franchise of sandwich restaurants
  • George DeLuca (1889-1983), American lawyer, banker and politician
  • Giorgio DeLuca, businessman and a founder of the gourmet grocery store Dean & DeLuca
  • Giuseppe De Luca (1876–1950), Italian baritone
  • Hector DeLuca, American biochemist and professor
  • Joseph Deluca (1893-1952), Italian-American mobster
  • Louis DeLuca (born 1933), American retired businessman and politician; former Connecticut state senator
  • Nick De Luca (born 1984), Scottish rugby union player
  • Rob De Luca, American rock bass guitarist
  • Rocco DeLuca (born 1975), leader and guitarist of the now-disbanded indie rock band Rocco DeLuca and the Burden
  • Sam DeLuca (1936-2011), American Football League lineman
Fictional characters
  • Maria DeLuca, fictional character in Melinda Metz's young adults book series Roswell High and the TV series Roswell
  • Detective Achille De Luca from Inspector De Luca, an Italian TV police drama set during Mussolini's reign, based on the novel series of the same name of Carlo Lucarelli