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Douglas Harper's Etymology Dictionary
defragment

1992, in computer sense, from de- + fragment. Related: Defragmented; defragmenting.

Wiktionary
defragment

vb. (context computing English) To run a process that collects fragment of files and sorts them into contiguous sections on one or more hard disk or hard disk partition, thus speeding up file management.

Usage examples of "defragment".

But she remained very still, soaking in the newfound moment as she watched her man defragment and begin to come back to himself.

Files on my laptop were encrypted with PGP and the hard disk had recently been defragmented so there was no danger there.

Quickly, I encrypted everything important on my laptop, defragmented the hard disk for good measure and hid the tiny but crucial Psion memory disk inside the apartment's television set.