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DDK abbreviation may refer to:

  • In software development, a Driver Development Kit, including Microsoft Windows Driver Development Kit
  • In hull codes of United States Navy, an abolished surface combatant warship category ' Hunter-Killer Destroyer'
  • In medical signs, Dysdiadochokinesia, a type of cerebellar ataxia
  • In molecular biology, Cdc7/Dbf4 kinase, or Dbf4-dependent kinase, — protein kinase required for initiation of eukaryotic DNA replication.