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DDF may refer to:

  • Digestive Disorders Foundation, a British medical research charity
  • Digital distribution frame, a device which terminates digital data streams, allowing arbitrary interconnections to be made
  • 4,4'-Dinitro-3,3'-diazenofuroxan, an experimental high explosive
  • Disk Data Format, a structure describing how data is formatted across disks in a RAID group
  • Drop Dead Fred, a 1991 fantasy comedy film
  • Dubai Duty Free, a duty-free retailer
  • Sulfoxone, an anti-leprosy drug sold under “DDF” brand