Wikipedia
D-Yikes!
"D-Yikes!" is the sixth episode of the eleventh season and the 159th overall episode of the American animated sitcom South Park. It first aired on Comedy Central in the United States on April 11, 2007. In the episode, frustrated with men, Mrs. Garrison makes the boys write an essay on The Old Man and the Sea. The boys hire Mexican day laborers to do the job for them, but they misinterpret the term "essay." Meanwhile, Mrs. Garrison has become a lesbian and finds the bar she hangs out in is about to be taken over by Persian club owners. Mrs. Garrison takes a stand in the name of saving the one place that lets her be the woman she is.
The episode is rated TV-MA, and is a parody of the film 300.