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D-Deprenyl

D-Deprenyl, also known as or dextro-N-propargyl-N-methylamphetamine, is an MAO-B inhibitor that metabolizes into D-amphetamine and D-methamphetamine and is therefore also a norepinephrine-dopamine releasing agent. It is the opposite enantiomer of L-deprenyl (selegiline).

L-Deprenyl, also an MAO-B inhibitor, metabolizes to L-amphetamine and L-methamphetamine, which are both norepinephrine releasing agents. In contrast, D-deprenyl additionally has dopaminergic effects and has been found to be reinforcing in scientific research, whereas L-deprenyl is not known to have any appreciable psychological reinforcement.

In addition to its actions as an MAO-B inhibitor and NDRA, D-deprenyl has been found to bind with high affinity to the σ receptor (K = 79 nM) similarly to various other amphetamine derivatives. Its L-isomer, selegiline, binds with 3.5-fold lower affinity in comparison.