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CSCS may refer to:

  • Colorado Springs Christian School;
  • Coral Springs Charter School;
  • Swiss National Supercomputing Centre;
  • Certified Strength and Conditioning Specialist, a United States recognized professional designation;
  • Construction Skills Certification Scheme, a United Kingdom recognized professional designation;
  • cc gene, a gene that can turn a cat's eyes blue due to a reduced number of melanocytes, affecting pigmentation of the eyes (see Cat coat genetics).