CSCS may refer to:
- Colorado Springs Christian School;
- Coral Springs Charter School;
- Swiss National Supercomputing Centre;
- Certified Strength and Conditioning Specialist, a United States recognized professional designation;
- Construction Skills Certification Scheme, a United Kingdom recognized professional designation;
- cc gene, a gene that can turn a cat's eyes blue due to a reduced number of melanocytes, affecting pigmentation of the eyes (see Cat coat genetics).