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Crighton may refer to:

  • Cameron Crighton, British actor, played Kevin Smith on Channel 4 soap opera Hollyoaks
  • Crighton Porteous or Crichton Porteous, (1901–1991), writer about life in the Peak District of northern England
  • David Crighton FRS (1942–2000), British mathematician and physicist
  • Hec Crighton, Canadian football coach
  • Michael Crichton or Michael Crighton, (1942–2008), American author, producer, director, and screenwriter
  • Richard Crighton, real estate developer and broker from Las Vegas, Nevada
  • Harry M. Crighton, oil businessman, mayor of Conroe, TX, and founder of the Crighton Theatre