CPX may refer to:
- Benjamín Rivera Noriega Airport (IATA code), Puerto Rico
- Dipropylcyclopentylxanthine, a drug
- Clinical performance exam, formally objective structured clinical examination, a prerequisite to working in various health care fields
- Clinopyroxene, monoclinic pyroxene, an igneous and metamorphic mineral
- The Centre for Public Christianity (CPX) is a not-for-profit media company that offers a Christian perspective on contemporary life.